Cleanroom Design Optimization

Computational Fluid Dynamics for Cleanroom Design

SimScale is a 100% cloud-based CAE software for cleanroom design simulation that lets you test, validate, and optimize your designs through computational fluid dynamics.


Cleanrooms are required for activities performed under a controlled environment and containing a low level of pollutants, such as pharmaceutical research and semiconductor manufacturing. One way to ensure a proper cleanroom design is through engineering simulation, especially computational fluid dynamics. Depending on the application, contaminating particles are often found in cleanrooms, and if not designed properly, could have negative effects on the product and those inside the lab. One cost-effective way to ensure contamination control is through SimScale’s CFD analysis solution. Cleanrooms can use up to 50 times more energy than non-classified areas, which can get expensive. With high regulatory standards, optimizing energy efficiency is not only necessary but can have added financial benefits. Using simulation software as part of the design process, design engineers can evaluate their design performance, optimize airflow and air change effectiveness, decrease the risk of contamination, and increase energy efficiency.

Air Change Effectiveness

Asess air circulation flow patterns. With this simulation focus, you can identify zones of the cleanroom that might be troublesome to ventilate.

Contaminant Distribution

The CFD analysis enables you to predict the behavior of the contaminant within the room. Tracking will allow a greater control over potential work hazards.

Air Flow Speed Efficiency

Evaluate the air speed withing the room. Identify areas of high flow velocity. Modify the room design to ensure steady air movement throughout the whole domain.

Energy Efficiency

Analyze temperature distribution within the room or the cooling or heating performance of room components. Ensure steady operational conditions for lab equipment.

Multi-Operation State Analysis

Investigate the air flow withing the room at different operation conditions. Check the performance of laminar chambers, suction systems, safety ventilation.

Purge Time

Calculate the time required to remove all contaminants and to exchange the air within the cleanroom.



Clean Room for Electron Microscope 

Optimizing a Clean Room for an Electron Microscope

Thermo-Consult is an engineering office specialized in HVAC & R systems that created a multi-operational state ventilation system in a clean room for an electron microscope. The engineers at the company used SimScale to investigate the airflow for ensuring that the temperature does not exceed certain values and that the air speed in different places is not above the limits.

Ventilation in a Cleanroom 

How to Ensure Proper Ventilation in a Cleanroom with CFD

Ventilation plays an important role in designing cleanrooms and in principal achieving an energy efficient model and for lowering operating costs. Some of the energy efficient concepts are to reduce exhaust, room size, room air leakage, pressure drop and simultaneous heating and cooling. All can be analysed using CFD software.


Browse through public simulations

SimScale Community gives you access to completed public simulation projects for free. Use their
setup as a template and perform Fluid Dynamics,  Thermal and Solid Mechanics analyses.




Christopher Quijano

I have used a lot of simulation packages over the past 25 years, including Nastran, Ansys, SolidWorks, and a whole host of others. I have been using SimScale for about nine months now and it has become my goto simulation tool. It allows me to run models larger than I have ever conceived on my own workstation.

Christopher Quijano
Mechanical Engineer at MSA, United States