For temperature-sensitive biopharmaceuticals, freezing and thawing rooms along with processes, equipment, and freeze-thaw chambers need to function at their best to avoid premature degradation, minimize the risk of microbial growth, and prolong shelf life. Controlled freezing and thawing rates are absolutely crucial to maintaining stability and quality of biotech and biopharma products, particularly where proteins are involved. Uncontrolled freezing and thawing can quickly alter a product’s properties and even lead to product loss. Take a look at this application guide for more information on using SimScale’s simulation platform for freezing and thawing applications.
Typical Freezing and Thawing Unit Applications
Freezing and thawing units are used in applications including but not limited to:
Pharmaceuticals and biopharma
Food production and gastronomy
Why is Online Simulation with SimScale Needed for Freezing and Thawing Unit Applications?
Where airflow and heat are concerned, simulation can be extremely useful in assessing and improving HVAC design. Using online simulation you quickly and easily visualize air behaviour and identify areas of recirculation or unstable temperatures. Whether assessing an existing thawing unit or optimizing a design before construction, simulation offers engineers the results they need to ensure a stable and controlled environment for freezing and thawing processes. As an example, watch this webinar on HVAC cold room design via the button below.
In addition to adequate freezing and thawing equipment, an important contributor to freeze-thaw stability is proper HVAC design. Biopharma products can be extremely sensitive to temperature, air, and light exposure. Maintaining consistent freeze-thaw rates for all products within a cabinet relies on valid assessment of photostability, airflow, heat transfer, and average ambient temperatures. See how CFD can be used to assess airflow in healthcare environments in this webinar.
This thawing room simulation demonstrates how online CFD can be used to analyze airflow and mean age of air within a thawing room. By analyzing these factors, an HVAC design engineer is able to ensure that products within the unit thaw at a consistent rate, whether on higher or lower shelves.
When a client wanted to analyze the air flow within a thawing room where 20 frozen packs are thawed at -40 degrees C, SimScale created a simulation to enhance understanding of air changes and local mean age of air within the design. See the initial results of the convective simulation performed and how the results led to improvements in the design in this presentation. View the slides here:
SYSTAG reduced heat flux variation in a lab reactor system by 60% with SimScale
“The support of the engineers at SimScale was crucial to get fast and accurate results as well as overcome any minor obstacles encountered in the process.”
Fluence Analytics virtually tested 25 different design configurations within minutes
“We wanted to incorporate computer-aided engineering (CAE) to better understand our design choices without having to execute many expensive prototype runs. Without the use of SimScale, we would have had to allocate more money to test our design choices. By applying numerical simulations we managed to establish an efficient and cost-effective way to gather data used in design choices.”
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