I believe you center of rotation is dependent on what kind of case your are simulating. For example if its just a simple rotating wheel, your center of rotation would be the center of the wheel. If its say an aerofoil, then your center of rotation would be the aerodynamic center. Deducing these values and inputting them into the result control will allow you obtain accurate moments as they require a specific reference point to deduce moment values/coefficients.
Lift and drag coefficients on the other hand are much more simple to set. They require you to select your surface which you want to calculate the lift and drag coefficients from and then define the direction of the forces. Back to the aerofoil example if you want to calculate lift for an aerofoil at a 0 degrees angle of attack, the lift force direction would be vertically upwards while drag direction is backwards and parallel to the incoming airflow.
On how to set the direction, its a matter of just denoting the which axis is the force direction axis. If your lift direction is in the positive Y axis for example, you just set the X and Z value to 0 and Y as 1. This can applied to all cases.
Hope this helps!