What does this mean?

The flow region could not be created. Please consider cleanup operations in your CAD tool.

Hey there!

Well, STL models give this problems form then to then. In your particular case, I think that the problem is with bad triangulation and some warped surfaces. Have a look at the hands for example:

image

I am not sure this is the exact source of the reported error, or the only one, but I know you need to use a better model for simulation.

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Well this happens because it’s an edited rigged model. I saw it hoping that it didn’t give any problems.